NSAIDs such as Rimadyl, carprofen, and Metacam are commonly prescribed to help dogs manage pain and inflammation, but pet parents may also have questions about their potential effects on the liver. Supporting your dog’s overall health while they take long-term medication often means paying attention to veterinary monitoring, diet, and any supplements your veterinarian recommends. If you are considering a liver supplement for a dog taking NSAIDs, understanding the ingredients, potential benefits, and safety considerations can help you have a more informed conversation with your vet.
Is your dog taking any of the following NSAIDS (Nonsteroidal anti-inflammatory drugs)?
- carprofen (Novox or Rimadyl)
- firocoxib (Previcox)
- deracoxib (Deramaxx)
- meloxicam (Metacam )
If your answer is yes, your veterinarian will likely recommend S-Adenosyl Methionine (SAM-e) to help maintain proper liver function. SAM-e protects the liver from damage caused by regular use of NSAIDS and supports cell regeneration and helps counteract canine cognitive dysfunction.
Related: 10 Best Liver Supplements for Dogs
In addition to liver support, studies have also shown it’s ability to help alleviate the symptoms of joint pain. This can be especially synergistic as many people are already giving their dog an NSAID for the purpose of treating joint pain & inflammation.
SAM-e does not required a prescription and can be purchase online. When choosing a SAM-e supplement, always look for:
- MADE IN THE USA in FDA, USDA and FSIS regulated manufacturing facilities for safety and purity.
- VITAMINS: A supplement should also include amino acids, B Vitamins, B6 and Zinc.
- HIGH ABSORPTION RATE: Our special enteric coating allows the tablets to survive through the stomach and be properly absorbed in the small intestine.
Project Paws SAM-e Advanced is recommended to help maintain proper liver health and brain function in dogs. Like all Project Paws products, its covered by the Project Paws Promise: if you’re not completely satisfied within 90 days, we’ll refund your purchase no matter how much you’ve used.
Supporting Your Dog’s Liver Health While Taking NSAIDs
Keeping a dog healthy while taking Rimadyl, carprofen, Metacam, or another NSAID starts with following your veterinarian’s dosing and monitoring recommendations. A liver support supplement may be appropriate for some dogs, but it should complement veterinary care rather than replace regular bloodwork or other recommended monitoring. Before adding any supplement, talk with your veterinarian about your dog’s medications, health history, and individual needs to make sure it is a safe choice.
More Resources
- PetMD: “What Can SAM-e Do for Dogs?”
- VCA Veterinary Hospitals: “What is SAMe?”
- PetCoach: “S-Adenosylmethionine (SAMe): An Aid to Managing Liver Disease in Dogs and Cats”
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional.
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