11 Best Liver Supplements for Dogs

Written by: Molly Weinfurter
Molly Weinfurter is a writer for iHeartDogs, and she’s passionate about helping animals in need. She volunteers for Bailing Out Benji and a local dog rescue.Read more
| Published on September 6, 2023
iHeartDogs is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no extra cost to you.

There are a lot of reasons to seek out the best liver supplements for dogs, especially if your pup has compromised liver health and function. These supplements boost the performance of canine organs, help with natural growth, and provide balanced nutrition.

Also, these supplements support liver healing through the action of cell-repairing antioxidants, detoxification, and increased protein synthesis. However, due to high competition in the market, finding the safest and most effective one can be challenging.

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So, we have provided a list of the top ten best liver supplements for dogs, which are highly effective and have no major side effects. Hopefully, at the end of this article, you’ll be able to decide on the perfect one for your dog.

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Best Liver Supplements For Dogs: Premium Picks

Quick Picks

If you’re in a hurry, here’s an overview of the best products:

  1. iHeartDogs Advanced Liver Support Supplement
  2. Zesty Paws Liver Supplement
  3. Coco And Luna Liver Supplement
  4. VetriScience Laboratories Vetri Liver Canine
  5. Coco And Luna Liver Supplement (Powder)
  6. Wanderfound Natural Liver Support
  7. Vet Classics Liver Support Supplement
  8. Coco And Luna SAMe Premium Supplement
  9. Coco And Luna Milk Thistle Liver Detox(Drops)
  10. NaturVet Senior 5-in-1 Supplement
  11. Maxxipaws Liver Supplement

1. iHeartDogs Advanced Liver Support Supplement

iHeartDogs Advanced Liver Support

The iHeartDogs Advanced Liver Support supplements are soft, chicken-flavored chews that most dogs will gobble up, thinking they’re normal treats. Yet, these tasty supplements can provide numerous benefits for dogs, including supporting the liver’s normal detox process, supporting proper kidney function, boosting the immune system, and easing joint stiffness.

Milk thistle, curcumin, cranberry extract, dandelion root extract, and yellow dock root are the key ingredients in these supplements. All these pet-safe ingredients work together to keep your pup feeling as healthy as possible. Plus, every time you purchase this product, 14 healthy meals are donated to shelter dogs.

Feeding Instructions

Under 25 lbs = 1 Chew

26-75 lbs = 2 Chews

Over 76 lbs = 3 Chews

In A Nutshell

These chewy, chicken-flavored supplements use milk thistle, curcumin, and cranberry extract to support the liver’s normal detox process while also aiding kidney function.


  • Helps the liver’s normal detox process
  • Also benefits the kidney, joints, and immune system
  • Soft, chicken-flavored chews
  • Packed with antioxidants
  • Only uses simple, natural ingredients
  • Donates meals to shelter dogs


  • Some dogs may dislike the flavor

2.  Zesty Paws Liver Supplement: Best For Healthy Liver

Zesty Paws liver support bites are chewable supplements and are one of the best options on the market. These are rich in milk thistle extract, BioPerine, turmeric, curcumin, dandelion root powder, and choline. These healthy elements support canine liver health and also help with kidney support. The supplements detoxify the dog’s liver and keep it healthy and functional.

Each 110 mg chew contains a standardized milk thistle extract that supports the liver’s normal detoxifying process. This supplement also contains N-acetyl cysteine (NAC) and dandelion root powder to provide additional support for your dog’s liver activity.

These soft chews have a mouthwatering chicken flavor that your dog will love. Additionally, there are no known side effects from using these supplements.

Feeding Instructions

Up to 25 lbs = 1 chew

26-75 lbs = 2 chews

Over 75 lbs = 3 chews

In A Nutshell

Most customers found this liver supplement for dogs beneficial, but a few think it’s challenging to serve because their dogs dislike the flavor. However, it’s a great option because its effective ingredients don’t cause major side effects.


  • High quality
  • Appealing taste
  • No synthetic colors used
  • Provides liver support and liver detoxification
  • Helps with kidney support
  • Easily chewable bites
  • No preservatives


  • Some dogs refuse to eat it


3.  Coco And Luna Liver Supplement (Tablets): Best For Liver And Kidney Support

Coco and Luna’s liver supplements help eliminate waste substances and toxins from your dog’s liver and kidneys. This supplement contains milk thistle, a powerful and safe ingredient that provides liver support for a dog by removing toxins. It’s a cleanser for the impurities found in your dog’s liver and it assists with overall kidney support.

Additionally, it contains Vitamin B-complex, which helps maintain body functions and promotes longevity. Along with those vitamins, it also features essential fatty acids such as DHA and EPA found in fish oil, which can protect your dog’s skin and coat. Luckily, this product doesn’t have any known side effects.

Feeding Instructions

Less than 25 lbs = 1 tablet

25-50 lbs = 2 tablets

51-75 lbs = 3 tablets

75 lbs and up = 4 tablets

In A Nutshell

Most owners found it useful for their dogs, but a few had trouble because their dogs found the smell unappealing. Yet, it’s one of the best because of its effective ingredients that have no major side effects.


  • Improves dog liver enzymes
  • Easy-to-serve powder
  • Supports healthy waste elimination
  • Provides kidney support
  • Eliminates toxins and removes damaging free radicals


  • Caused digestive issues in a few dogs


4.  VetriScience Laboratories Vetri Liver Canine: Best For Liver Enzymes

Vetri Liver Canine is designed to support liver health by using methylation and detoxification functions. This supplement contains fifteen liver support ingredients, such as milk thistle and whey protein isolate, in a highly palatable chicken-flavored formula.

It supports phase 1 and phase 2 liver detoxification pathways. The first detoxification phase involves neutralizing unwanted chemicals, such as free radicals, which can damage liver cells. The product contains nutrients such as B vitamins, vitamin E, folic acid, glutathione, and other antioxidants that help eliminate free radicals and detoxify harmful substances.

During phase 2, unwanted substances are converted into water-soluble chemicals excreted via urine and bile. Vetri Liver Canine contains glutathione, turmeric, and cysteine to support the liver pathway.

Feeding Instructions

Give one chew per 30 lbs of body weight daily.

In A Nutshell

Most buyers found this supplement beneficial when coupled with a healthy diet. A few users found the smell of the chews repelling. Overall, it’s a great option for your dog because of the natural ingredients with detoxification functions.


  • Natural chicken-flavored chews
  • 15 unique liver support ingredients
  • Helps in phase 1 and phase 2 detoxification
  • No known side effects


  • Strong smell



5.  Coco And Luna Liver Supplement (Powder): Best For Mental Health

Coco and Luna’s liver supplement powder supports your dog’s liver health by protecting the liver from damage and supporting metabolic activity and cell regeneration.

This liver supplement contains milk thistle, dandelion root, and Vitamin B for dogs and cats. Those items are safe and powerful natural ingredients that detoxify impurities, eliminate toxins, and remove damaging free radicals.

The advanced formula of this supplement supports healthy waste elimination and promotes normal hepatic functions and liver health in dogs. It contains the best natural ingredients, adjusted for pets in an easy-to-serve format that can be given as a food topper.

These supplements are manufactured in FDA-registered facilities that are NSF- and GMP-certified in the USA. That’s why they are one of the best products on the market.

Feeding Instructions

Less than 25 lbs = 1 scoop

25-50 lbs = 2 scoops

51-75 lbs = 3 scoops

75 lbs and up = 4 scoops

In A Nutshell

Most buyers found it useful for their dogs, but a few owners reported digestive issues after a few days. But since the majority found success, it’s one of the best dog liver supplements because of its ingredients and certifications.


  • Improves dog liver enzymes
  • Supports healthy waste elimination
  • Provides liver support
  • Eliminates toxins and removes damaging free radicals
  • Easy-to-serve powder


  • Caused digestive issues in a few dogs



Related: 7 Best Digestive Enzyme Supplements For Dogs

6.  Wanderfound Natural Liver Support: Best For Liver Detoxification

This liver supplement improves your dog’s liver health because of its special formula. This excellent liver cleanser protects your pup from toxins and other impurities.

The S-adenosylmethionine (SAM-e or SAMe) in this supplement helps maintain your dog’s optimal liver function. Also, it strengthens memory and cognitive functions by supporting the neurotransmitters in your dog’s brain.

This premium liver detox formula is carefully manufactured in the USA without by-products and is made with only quality, safe ingredients. These chewable supplements are perfect for dogs of all ages, weights, and breeds. Also, they’re easy to serve because of the mouth-watering flavor.

Feeding Instructions

Up to 11 lbs = 1 tablet

11-22 lbs = 2 tablets

Over 22 lbs = 3 tablets

Start with one tablet daily and gradually increase as needed. Allow 3-4 weeks to notice a response. Then, adjust as needed. Store in a cool, dry place.

In A Nutshell

Most dog owners have positive reviews about this supplement as it has been beneficial in improving liver enzymes. However, a few found it hard to swallow for their dogs.


  • Natural ingredients
  • Helps with proper organ functions
  • Promotes pancreas health
  • Supports kidney health
  • Supports overall wellness


  • Hard to swallow for small dogs


Related: 9 Best Glucosamine Supplements for Dogs [2023]

7.  Vet Classics Liver Support Supplement: Best For Immune System


The Vet Classics liver supplement helps support normal liver function for dogs. It’s made with a blend of supportive enzymes, herbs, prebiotics, vitamins, and probiotics that help support the overall health of the liver. Some major ingredients include milk thistle, dandelion root, and glutathione.

This supplement contains superoxide dismutase and vitamins that help strengthen the immune system by scavenging free radicals. The formulation of this pet health supplement supports healthy liver functions for dogs, especially seniors, by managing toxins to strengthen pet immunity.

Each soft chew of this liver support supplement is infused with herbal ingredients and a complex blend of enzymes to support healthy liver function and help support overall wellness for dogs. The Vet Classics liver supplement is formulated and manufactured in the USA and is FDA-audited, making it one of the best liver supplements for your pet.

Feeding Instructions

Under 30 lbs = ½ tablet

31-60 lbs = 1 tablet

Over 61 lbs = 2 tablets

In A Nutshell

This supplement is widely used and is one of the best liver supplements because of its softness and natural ingredients. Also, it has no known side effects. The only downside is that it’s a bit pricey.


  • High quality
  • Effective
  • Supports immunity in dogs
  • Veterinarian formulated
  • Natural ingredients


  • A bit pricey


8.  Coco And Luna SAMe Premium Supplement: Best For Brain And Liver

Coco and Luna’s SAM-e supplement works to enhance cognitive and memory functions for cats and dogs of all ages. Its natural formula contains choline and inositol, which promote brain and hepatic health by protecting the liver from damage and supporting metabolic activity.

This supplement has effective natural ingredients formulated for dogs in a powder that can be given as a food topper or snack. It supports dogs’ mental and cognitive health because the choline and inositol promote brain health.

Also, it supports liver health by protecting the liver from damage and supporting metabolic activity and cell regeneration. Furthermore, it is very easy to use. Just mix the powder into your pet’s food daily for easy feeding.

Feeding Directions

Less than 25 lbs = 1 scoop

25-50 lbs = 2 scoops

51-75 lbs = 3 scoops

75 lbs and up = 4 scoops

In A Nutshell

Many people like this liver supplement because of its dual functionality. Also, it is made from natural ingredients and has no known side effects. The only downside to this supplement is that it’s unappealing for some dogs.


  • Easy to serve
  • Natural
  • Effective
  • Beneficial for liver and brain function
  • FDA-registered


  • Unappealing for some dogs


9.  Coco And Luna Milk Thistle Liver Detox: Best For New Liver Cell Growth

This Coco and Luna supplement contains milk thistle, which promotes detoxification and maintains the normal balance of fluids and minerals in dogs. The formula activates protein synthesis and stimulates the growth of new liver cells to replace those dead or damaged while maintaining healthy liver function.

It uses high-quality natural ingredients that are adjusted for dogs in a liquid format that can be given with food or directly by mouth. This supplement is manufactured in FDA-registered NSF- and GMP-certified facilities in the USA.

Also, it is hypoallergenic and approved by veterinarians. This milk thistle liquid formula may help with liver detox and bring overall liver support to your dog.

Feeding Directions

Up to 25 lbs = 1 dropper

26-50 lbs = 2 droppers

51-74 lbs = 3 droppers

Over 75 lbs: 4 droppers

In A Nutshell

Most people find it very effective for their dog’s liver, but a few people didn’t find it as effective. Overall, we recommend it because of its natural ingredients and reliability.


  • Organic milk thistle
  • Promotes detoxification
  • Easy-to-serve drops
  • Reliable
  • FDA-registered
  • NSF and GMP certified


  • It may cause vomiting in a few dogs

10. NaturVet Senior 5-in-1 Supplement: Best For Overall Body

This premium pet health supplement fuels your dog with antioxidants to help support eye health, liver and heart function, and cognitive function in dogs. It’s most effective for senior dogs.

Each soft chew supplement features flavoring that’s appealing for dogs. It’s made with a blend of ginkgo biloba, lutein, milk thistle, and coenzyme Q10 to support your dog’s overall health.

Also, this is an ideal supplement for your dog’s heart rate because it helps encourage activity and comfort when feeding your dog. This dog supplement helps support the immune system, eye, heart, and liver health. It gives your furry friend’s immune system a boost, especially when aging, because of the turkey tail mushroom, ginkgo biloba, and lutein in it.

Feeding Instructions

Up to 20 lbs = 2 soft chews

21-50 lbs = 4 soft chews

51 lbs and over = 6 soft chews

In A Nutshell

This liver supplement is great because it has multi-functionality and is made from natural ingredients. The only downside about this supplement is that it is not ideal for small dogs.


  • Supports eye health
  • Heart health
  • Ideal for senior dogs
  • Helps the immune system
  • No known side effects


  • Not ideal for small dogs



11. Maxxipaws Liver Supplement: Best For Senior Dogs

Maxxipaws SAM-e is a recommended supplement for supporting and maintaining healthy liver function in dogs. SAM-e supplementation supports the liver metabolic activity, helps maintain the glutathione level in the body, and supports cell regeneration.

This product contains a patented stabilized powdered form of SAM-e that guarantees the availability of SAM-e when taken orally and protects it from interactions with environmental factors. It also supports brain function and can benefit senior pets with mental confusion.

Plus, it contains additional ingredients that support canine hepatic and brain function: artichoke (from the thistle family), choline, and inositol. It also has B Vitamins that improve the absorption of SAM-e.

Feeding Directions

7.5 lbs = ¼ scoop

Up to 15 lbs = ½ scoop

Up to 22.5 lbs = ¾ scoop

30 lbs and over = one scoop

In A Nutshell

This is a great liver supplement because it has multi-functionality and is made from natural ingredients. The only downside of this supplement is that it is not ideal for small dogs.


  • Supports liver and brain health
  • Supports cell regeneration
  • Helps with mental confusion
  • Made in the USA
  • No known side effects


  • Not ideal for small dogs

Puppy in basket

Factors To Consider Before Buying Liver Supplements For Dogs

All the supplements we reviewed are great choices for your dog’s liver. But in order to decide on the perfect one, make sure to consider these factors:

1.   Dosage Of Supplement

Before buying any liver supplement for your dog, you must consider what it’s used for and how often your dog will take it. The dosage of the supplement might affect your dog’s health and put them at risk if you don’t follow it closely.

So, always check the usage of the supplement you are going to buy. If you’re unsure if it’s safe for your dog, talk to your vet first.

2.   Features

Next, consider the features of the supplement you will buy for your dog. You’ll need to make sure it benefits your dog in the necessary areas. In this instance, liver health is likely your priority.

Always go with the supplement that focuses on your dog’s needs. That way, you can narrow down your search to find the most reliable option.

3.   Cost

Cost is one of the most important factors before buying the best liver supplements for your dog. High-quality products are generally expensive, and low-quality products are less expensive. However, pricey supplements often have better results or more benefits, so you need to ask yourself if you’re willing to sacrifice those benefits for a better price.

If you have a tight budget, go with the one with fewer features. As long as it focuses on liver health, that’s what matters most. Then, you can save money while still getting an effective product.

Related: The 4 Best Supplements for Puppies (+1 to Avoid)

Frequently Asked Questions

Do Dogs Need Liver Supplements?

Dogs with impaired liver function benefit from liver supplements, but did you know that they can also help healthy dogs?

During a dog’s life, the liver can be affected by chronic exposure to toxins, parasites, medications, infections, and stress. The ability of this highly important organ can also be impaired by additional factors, such as old age, genetics, and diet.

So, to deal with all these things, a liver supplement is essential, even for a healthy dog.

What Are The Benefits Of Liver Supplements For Dogs?

  • These supplements boost the functionality of their organs
  • They help in natural growth and provide balanced nutrition
  • These supplements support liver healing through the action of cell-repairing
  • They support the liver with antioxidants and a detoxification process
  • They increase protein synthesis.

How Can Supplements Help With Liver Problems In Dogs?

The treatment of liver disease in dogs depends on the cause and the severity of the damage to the liver. Hospitalization, medicine, or surgery may be required depending on the liver problem. A liver supplement can provide nutritional support if a dog’s liver is damaged by disease.

Through the action of cell-repairing antioxidants, increased protein synthesis, and detoxification, liver supplements for dogs that contain milk thistle, silybin, omega-3 fatty acids, and glutathione can help support liver healing.

What Ingredients or Nutrients Can Help My Dog’s Liver?

The liver plays a crucial role in your dog’s health, carrying out important functions like detoxification, protein synthesis, and the production of chemicals necessary for digestion. A balanced diet is essential to keep your dog’s liver functioning well. Here are some ingredients that are believed to be beneficial for liver health:

  1. Protein: A source of high-quality, easily digestible protein is important. This includes lean meats like chicken, turkey, and fish. However, excessive protein can be harmful for a dog with liver disease, so it’s important to adjust the quantity based on your dog’s specific needs.
  2. Omega-3 Fatty Acids: These help reduce inflammation and can support liver health. Fish like salmon and sardines are excellent sources of omega-3 fatty acids.
  3. Milk Thistle: This is often used as a natural supplement for liver health, as it’s believed to have protective effects on the liver and improve its function.
  4. Vegetables: Leafy green vegetables like spinach, kale, and broccoli can support liver function because they’re high in antioxidants and other beneficial compounds.
  5. Blueberries and other berries: These fruits are packed with antioxidants that can help protect the liver from damage.
  6. Garlic: Small amounts of garlic can be beneficial for the liver, as it contains compounds that aid in liver detoxification. However, be aware that excessive garlic can be toxic to dogs, so it’s best to use it sparingly and consult with your vet.
  7. Sweet Potatoes: These are a good source of dietary fiber and antioxidants, which can help support liver health.
  8. Probiotics: These can help maintain a healthy gut flora, which in turn supports liver health. They can be found in certain types of yoghurt or as a supplement.

Before you make any changes to your dog’s diet or introduce new supplements, you should always consult with a veterinarian. If your dog has a liver disease, the diet must be carefully managed, as there are certain foods and supplements that can be harmful in these cases. For instance, too much copper can exacerbate liver issues, and certain medications may interact with supplements like milk thistle.

Wrap-Up: Best Liver Supplements for Dogs

Overall, Coco and Luna’s liver supplements are the best in all aspects. But you should consider all your options to decide which one is perfect for your dog’s needs.

Hopefully, you now have enough information to pick the best liver supplement for your dog. Your pup will thank you in the long run!

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