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4 Best Supplements for Great Dane Puppies (+1 to Avoid)

Written by: Arlene Divina
Arlene Divina, one of the content writers at IHD, loves going on adventures with her adorable fur baby. She now creates informative content for pet parents. Read more
| Published on October 31, 2022
Great Dane puppy best supplements
iHeartDogs is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no extra cost to you.

The health of our loved ones is one of the most precious things in life. It’s an asset that’s irretrievable once lost. For Great Dane parents, one of the biggest priorities is the health of their adoring puppies, who are totally dependent on them. That’s where supplements for Great Dane puppies come in.

A significant part of a Great Dane puppy’s health depends on what you put in their tummies. In addition to healthy dog food, essential supplements for your furry friend can have life-changing effects. They can enhance growth, protect against diseases, and improve cognitive ability.

Puppy supplements can be a crucial factor when it comes to your pup’s future.

“But Why Use Supplements for My Great Dane Puppy When I Feed a High Quality Dog Food?”

Any nutritional deficiency can harm your Great Dane puppy’s health. Unless you’re feeding them the highest quality dog food, they’re likely missing out on essential nutrients for their growth.

Even if your puppy is getting the most well-researched food, they may still benefit from a supplement, depending on their health and breed. However, excessive amounts of nutrients can deteriorate your dog’s health, doing more harm than good.

Hence, it’s vital to choose a proper supplement for your growing puppy. Lucky for you, we have researched a variety of the best supplements for puppies on the market. Each one serves a different purpose.

#1 – Omega-3 Fatty Acids for Great Dane Puppies

Your puppy is still in their learning and development phase. They’re likely in training, which is as much of a mental process as a physical one. You’re likely keeping their needs in check, but are you sure they’re getting enough nutrients for proper cognitive development?

Omega-3 is a type of essential fatty acid (EFA) that’s extremely important for the cognitive development of puppies. Nearly half of the brain is made up of fat, and a significant percentage of that fat is docosahexaenoic acid (DHA), a type of omega-3 fatty acid. 

Unfortunately, most dog foods don’t have enough omega-3s. A puppy’s body can’t produce omega fatty acids by itself, so it needs to get them from external sources. Thus, if there’s not enough in their food, it has to be provided as a high-quality supplement. 

Overall, omega fatty acids can help with brain and eye development, heart health, inflammation, skin and coat, and energy.

Our Favorite Omega-3 is the iHeartDogs Omega 3-6-9 Chews

iHeartDogs omega supplements


iHeartDogs Omega 3-6-9 is one of the best products on the market for essential fatty acids. It’s especially great for keeping your pup’s skin and coat healthy. Even if your Great Dane puppy isn’t facing any issues, you can use it to ensure they get all the fatty acids they need.

These supplements contain two highly valuable types of omega-3: DHA and EPA, fatty acids which help with the cognitive development of young dogs. Also, this is one of the only dog supplements that contains gamma-linolenic acid (GLA), a type of omega-6 that fights inflammation and improves the cognitive function of puppies. It also contains omega-9, which improves the immune system and cholesterol levels. 

Benefits of Omega-3 for Great Dane Pups:

  • Helps with your Great Dane puppy’s brain development.
  • Contains anti-inflammatory fatty acids to protect against arthritis and ease joint pain.
  • Uses DHA to promote good eyesight.
  • Improves immune systems.
  • Enhances the condition of your Great Dane puppy’s skin and coat.
  • Boosts energy.

These are a few of the many health perks this product will bring to your puppy. However, it should be noted that fatty acids in high doses can have minor side effects, so be careful with the dose. When in doubt, ask a vet for their dosage recommendation.


#2 – Probiotics for Great Dane Puppies

Probiotics are friendly bacteria and yeast that spend most of their life inside the gut, fighting off bad bacteria and improving the digestive system. 

Humans, as well as dogs, need to have a balanced amount of good and bad bacteria to function properly. Unfortunately, bad bacteria sometimes outnumber good bacteria, causing health-related inconveniences. Some of the good bacteria in your puppy’s gut may die as a result. 

In those situations, it’s important to give your puppy relevant doses of probiotics, so the number of good bacteria rises enough to neutralize the effects of bad bacteria. Probiotics should be a regular part of a diet because they help enhance digestion, improve mental health, and boost the immune system.

Why Not Use the Usual Food Items that Contain Probiotics?

There are many food items we consume daily that fulfill our needs for probiotics, and we can let our puppies consume most of them without running any health risks. However, dog-specific probiotics are much more beneficial for your pup. Not only do dog probiotics have additional advantages for puppies, but they are also more effective.

Our favorite probiotic is the iHeartDogs 3-in-1 Probiotic Dog Chews

iHeartDogs probiotic supplement


There are many dog-specific probiotics on the market, but this is one of the best options for your puppy. These chews have all the previously discussed benefits, and they also contain prebiotics and digestive enzymes.

Prebiotics are food for good bacteria. They help the probiotics grow, so it’s wise to take them with probiotics. Digestive enzymes are the enzymes that aid in good digestion. 

Having all three of those items in a single chew makes this product a lethal weapon against a long list of common digestive issues that might irritate your puppy.

Benefits of Probiotics for Great Dane Pups:

  • Boosts the immune system.
  • Improves the health of the gastrointestinal tract (GI tract).
  • Helps with better absorption of nutrients.
  • Contains digestive enzymes.
  • Reduce stress and anxiety.
  • Contains prebiotics that enhance probiotics.


#3 – Dental Chews for Great Dane Puppies

Oral diseases are one of the most common health problems young dogs face. Bad habits such as not brushing their teeth can adversely affect their overall health. The problem may seem to only affect teeth, but it can also have a deteriorating effect on vital organs such as the liver and kidneys.

Healthy oral habits can prevent such complications. This starts with brushing your Great Dane puppy’s teeth, but sometimes, teeth brushing can be difficult. If you struggle to maintain a good oral routine, a pack of dental chews can be a lifesaver. 

Are Dental Chews as Good as Brushing for My Great Dane Puppy?

Although dental chews are very effective for good oral health, nothing is as effective as brushing your dog’s teeth. However, for the days when puppies refuse to cooperate, having some sort of cleanup is a million times better than doing nothing.

While puppies dislike teeth brushing, they usually love dental chews. Most dogs would never say no to a nicely-flavored stick. However, not all chews are equally effective. Low-quality products might not work as well, so you should invest in top-notch chews.

Our pups love the iHeartDogs Brushy Sticks Dental Treats

iHeartDogs brushy sticks


This product comes as a pack of 30 sticks that won’t only clean the tartar off your puppy’s teeth but will also help them have fresh breath all day long.

It’s especially good for puppies that have a complicated tooth structure and are difficult about getting their teeth brushed. It will also work for dogs who have grain allergies since it’s grain-free.

These chews clean teeth by brushing the plaque off as dogs gnaw on them, which prevents the tartar from slowly building up. Since tartar is the root of many oral health issues, taking steps to prevent it is essential.

Benefits Dental Sticks for Great Dane Pups:

  • Grain-free to protect puppies with allergies.
  • Made with real chicken.
  • Leaves your pup with minty-fresh breath.
  • Prevents tartar by not allowing plaque to build up.
  • Makes cleaning your dog’s teeth easy.


#4 – Protein Toppers or Boosters for Great Dane Puppies

Proteins are a necessary part of a well-balanced diet for younger dogs, just like they are for humans. Puppies need them for their growing muscles and bones, and for various other biological components and functions.  

Your puppy is not able to retain proteins for a long time, so they need to be fed protein regularly. While you can use everyday food items that are high in protein to fulfill your puppy’s requirements, it’s easier to use a high-quality supplement. 

A protein supplement will help you track how much protein you’re putting into your dog’s system and reduce the risk of feeding them too much.

Our test dogs went crazy for the iHeartDogs Nutrition Boost Beef Food Topper

Beef food topper


This food topper will add high-value ingredients to your regular dog food by introducing proteins, probiotics, and antioxidants. Its flavor can also make meals more appealing to picky pups.

Often, cooking burns the necessary nutrients in dog food, which may also contain essential proteins. By introducing this topper to your dog’s diet, you will make sure that your puppy is not missing out on proteins.

Since the topper contains probiotics, it’s a good defender against miserable digestive problems. If your dog is eating this topper, they may not need a probiotic supplement.

Benefits for Protein Toppers Great Dane Pups:

  • Improves the immune system.
  • Contains protein that helps with tissue development and repairs broken tissues.
  • Contains protein that helps make antibodies, enzymes, and hormones.
  • Makes meals more appealing to puppies.
  • Contains probiotics that promote a healthy gut.


Bonus: Supplements to Avoid for Great Dane Puppies

All the above are essential supplements that can drastically improve your puppy’s life if used properly. However, not every supplement on the market is needed. Certain ones are either useless or even harmful to your puppy, such as the following.

Does My Great Dane Puppy Need a Multi-vitamin?

Usually, a Great Dane puppy should be getting all the vitamins they need from a balanced diet, so providing multivitamins isn’t necessary. The following list may even harm your pup:

 ❌ Avoid Multivitamins Made for Humans

If you feel that your puppy requires multivitamin supplements, never give them multivitamins made for human use. A human tablet may contain a higher dose of vitamins than dogs need, and it may cause mild to severe complications for the puppy. It may also include ingredients that aren’t pet-friendly.

 ❌ Avoid Vitamin D and Prenatal Vitamins

Some multivitamins are highly toxic to dogs, such as prenatal vitamins. Prenatal vitamins contain high amounts of iron, potentially causing iron toxicity in puppies.

Also, high levels of vitamin D can cause serious harm to your puppy. It can even cause permanent organ damage.     

 ❌ Avoid Caffeine 

Never let your Great Dane puppy consume caffeine. Don’t even let them get close to it. It’s toxic for them and may even result in life-threatening medical conditions. Caffeine consumption may increase body temperature, cause seizures, and lead to cardiac arrhythmia.

So, be extra careful when it comes to caffeine. For us, caffeine is a life-saving drug that has gotten us through the most stressful situations, but for our dogs, it’s too dangerous.

 ❌ Avoid any supplement with Xylitol 

Xylitol is a very common artificial sweetener that’s safe for human consumption. However, it can be lethal for dogs. It can cause deteriorating effects on a dog’s health, even if consumed in small amounts. Xylitol may even cause an unfortunate death of a puppy. If any supplement contains even a trace of xylitol should be avoided at all costs. Note that xylitol is often labeled as wood sugar, birch sugar, or birch bark extract.

Conclusion – A Final Word on Great Dane Puppy Supplements

There are certain supplements you may give to your Great Dane puppy for a healthy lifestyle. Omega fatty acids are great for the brain, vision, skin, and coat. Prebiotics and probiotics are excellent for the gut. They can help your Great Dane pup avoid uncomfortable digestive problems.

Also, dental chews will help prevent tartar from accumulating on your puppy’s teeth. They can play a key role in achieving good oral health. Then, the protein topper will help with healthy growth, boost the immune system, and make food easier to eat.

Finally, as important as supplements are, you should be cautious with the supplements you choose. Certain supplements can be toxic and can even result in life-threatening conditions. 

A healthy lifestyle starts with a healthy diet. Considering the best supplements for puppies can improve your dog’s quality of life for years to come.

iHeartDogs is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no extra cost to you.

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