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7 Best SAM-e Supplement for Dogs

Written by: Arlene Divina
Arlene Divina, one of the content writers at IHD, loves going on adventures with her adorable fur baby. She now creates informative content for pet parents. Read more
| Published on July 5, 2023
iHeartDogs is reader supported. Some of the links below may be paid affiliate links, where we receive a small commission on a product at no additional cost to you. 

In the world of canine health and wellness, S-Adenosylmethionine, commonly known as SAM-e, has emerged as a game-changer. This naturally occurring compound in the body plays a crucial role in numerous biochemical reactions involving the liver and joint health. Yet, as our canine companion’s age or face certain health issues, their natural production may decline, necessitating a SAM-e supplement. This article delves into the best SAM-e supplements for dogs available in the market, focusing on their benefits, safety, and administration, to help you make an informed decision for your furry friend.


#1 – maxxipaws maxxiSAMe Sam e for Dogs – Dog Liver Support – Dog Brain Supplement – Dog Cognitive Supplement – Functional Liver Support for Dogs – Sam-e for Dogs Given with Food – Senior Dog Powder 5.3 oz

Maxxipaws maxxiSAMe is a powdered supplement for dogs that supports liver health and cognitive function. It contains a stabilized form of SAM-e, which helps maintain healthy liver function and supports brain function in senior dogs. The formula also includes additional ingredients that support canine hepatic and brain function, and the powder can be easily administered with food for accurate dosage.


#2 – Nutramax Denamarin Liver Health Supplement for Dogs, With S-Adenosylmethionine (SAMe) and Silybin, 30 Chewable Tablets

The Nutramax Denamarin Liver Health Supplement is a veterinarian-recommended product for dogs that supports liver health. It contains s-adenosylmethionine (SAMe) and silybin, which help increase levels of the antioxidant glutathione and aid in the absorption of nutrients. This supplement is produced by Nutramax Laboratories Veterinary Sciences, a reputable company known for their scientifically formulated and high-quality pet health products.


#3 – Wanderfound Pets Same 100 Liver Support for Dogs – Same S-Adenosyl-L-Methionine Hepatic Supplement for Liver & Brain Support – Bacon Flavored Sam E, Manufactured in The USA – 30 Chewable Tablets

The Wanderfound Pets Same 100 Liver Support for Dogs is a bacon-flavored chewable supplement designed to support a dog’s liver and cognitive health. Manufactured in the USA, each tablet contains 100mg of SAMe (S-Adenosyl-L-Methionine) and is suitable for dogs of all ages and sizes. The product aims to help dogs maintain optimal liver and brain health, allowing them to live a happy and active lifestyle.


#4 – VetriScience Vetri-Same Advanced Liver Support Supplement for Dogs with Glutathione, 225mg Tablets

VetriScience Vetri-Same Advanced Liver Support Supplement for Dogs is a supplement that contains SAMe and glutathione to support liver health in cats and dogs. It is an enteric-coated tablet that ensures effective absorption and bioavailability. This advanced formula aims to maintain the optimal health and function of your pet’s liver.


#5 – Same for Dogs – S-Adenosyl-L-Methionine, Same Premium, Liver Supplements for Dogs, Brain Supplement for Dogs, Promotes Cognitive Support, Dog Liver Support Supplement

This product is a liver and brain supplement for dogs, designed to support overall liver health, cognitive function, memory, and mental sharpness. The supplement is manufactured in FDA-registered facilities in the USA, and is veterinarian approved and hypoallergenic. It aims to improve liver and cognitive health in dogs.


#6 – ClearFormulas Sam-e for Dogs, S-Adenosyl-L-Methionine, 225mg 120 Chewable Tablets, Natural Hepatic Liver Health Support

ClearFormulas Sam-e for Dogs is a liver health supplement made with natural ingredients specifically formulated for easy absorption in pets. With its advanced formula, it claims to support liver health in dogs and is made with pure, premium ingredients. Additionally, it is manufactured in the USA.


#7 – K9 Select SAM-e for Dogs, 225mg – 60 Tablets, Cognitive and Liver Support Supplement for Dogs

K9 Select SAM-e for Dogs is a nutritional supplement designed to support liver function and promote cognitive function in dogs. Each tablet contains 225mg of SAMe, making it suitable for medium and large adult dogs. The enteric-coated tablets provide stability and enhance bioavailability, while also offering assistance for dogs with liver problems or joint troubles.


What Are The Benefits of Giving a SAMe (S-Adenosyl-Methionine) Supplement to My Dog?

SAMe, or S-Adenosyl-Methionine, has several potential benefits when administered as a supplement to dogs. Here are a few:

  1. Liver Health: SAMe is often used to support liver function in dogs. The liver is responsible for detoxifying the body, and SAMe can aid this process by promoting the production of glutathione, an antioxidant that protects liver cells from toxins.
  2. Joint Health: SAMe may also support joint health in dogs, especially those with arthritis or other joint disorders. It may help reduce inflammation and discomfort, thereby improving mobility and quality of life.
  3. Mental Well-being: SAMe has also been studied for its potential effects on canine cognitive dysfunction, a condition similar to Alzheimer’s in humans. Some research suggests that it may enhance brain health and function, potentially improving memory, attention, and activity levels in older dogs.
  4. Mood Regulation: Additionally, SAMe is involved in the synthesis of neurotransmitters like serotonin and dopamine, which are essential for regulating mood. Some evidence suggests it may help manage behavioral disorders and mood-related conditions, such as depression and anxiety.

Remember, while SAMe has these potential benefits, it’s crucial to consult with your veterinarian before starting your dog on any new supplement regimen. The vet will be able to provide personalized advice based on your dog’s age, breed, overall health, and specific needs.

Related: 11 Best Urinary, Kidney, & Bladder Supplements for Dogs

Frequently Asked Questions About SAMe Supplements for Dogs

  1. What is SAMe and what does it do in dogs?
    SAMe (S-Adenosyl Methionine) is a natural compound found in all living cells. In dogs, it aids liver function, joint health, cognitive function, and mood regulation. It promotes liver detoxification, reduces joint inflammation, and supports brain health and neurotransmitter synthesis.
  2. Is SAMe safe for dogs?
    Yes, SAMe is generally safe for dogs when used as directed by a veterinarian. However, like any supplement, it can have side effects and interactions. Always consult your vet before starting your dog on a SAMe regimen.
  3. What are the side effects of SAMe in dogs?
    Side effects are generally rare but can include vomiting, diarrhea, and lack of appetite. If you notice any adverse reactions, contact your vet immediately.
  4. How long does it take for SAMe to work in dogs?
    The effects of SAMe may not be immediately visible as it often takes a few weeks of consistent use to notice improvements, particularly in liver health or joint function.
  5. Can I give my dog SAMe meant for humans?
    It’s not advisable. While the active ingredient is the same, the dosages may vary, and human supplements may contain additional ingredients that aren’t safe for dogs. Always choose a product specifically designed for dogs.
  6. How is SAMe administered to dogs?
    SAMe is typically given orally in tablet form. It’s usually recommended to administer it on an empty stomach for best absorption.
  7. What should I do if I miss a dose of my dog’s SAMe supplement?
    If you miss a dose, give it as soon as you remember. If it’s close to the time for the next dose, skip the missed one and continue with the regular schedule. Never give two doses at once.
  8. Can SAMe be used alongside other medications?
    SAMe can potentially interact with certain medications. It’s crucial to discuss with your vet any medications your dog is currently taking before starting a SAMe supplement.
  9. Is SAMe effective for treating arthritis in dogs?
    SAMe can support joint health and may help reduce inflammation and discomfort associated with arthritis. However, it should not replace a comprehensive treatment plan recommended by a vet.
  10. Does SAMe help dogs with liver disease?
    SAMe is often used as a supplement to support liver function in dogs with liver disease. It can aid the liver’s detoxifying process and promote antioxidant production, but it’s not a substitute for veterinary care and should be used as part of a comprehensive treatment plan.

Related: The 4 Best Supplements for Puppies (+1 to Avoid)

Conclusion: Best SAM-e Supplement for Dogs

Choosing the right SAM-e supplement for your dog is an important aspect of maintaining their overall well-being. Whether you are focusing on liver health, joint function, or mental well-being, the right supplement can make all the difference. However, it’s important to remember that supplements should always be used under the supervision of a veterinarian and as part of a comprehensive health plan. Finding the right product can be a lifesaver, but it’s equally crucial to use it responsibly. Continue to research and consult with your vet to ensure that your dog is getting the best care possible.

iHeartDogs is reader supported. Some of the links below may be paid affiliate links, where we receive a small commission on a product at no additional cost to you. 

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